SNHG17 drives malignant behaviors in astrocytoma by targeting miR-876-5p/ERLIN2 axis

SNHG17 drives malignant behaviors in astrocytoma by targeting miR-876-5p/ERLIN2 axis

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Abstract Background Astrocytoma is a common tumor type in primary central nervous system and has a high death rate around the world.Aberrant expression of long non-coding RNAs (lncRNAs) has been introduced by emerging studies to result in the development of diverse cancers.Methods RT-qPCR examined the expression of SNHG17, miR-876-5p and ERLIN2, and western blot evaluated ERLIN2 protein level.RNA pull down and luciferase reporter assays illustrated the relationships between SNHG17 and its downstream molecules.Results SNHG17 was up-regulated sukin body lotion woolworths in astrocytoma cells.

Moreover, SNHG17 silence could repress the proliferation, migration and invasion of astrocytoma cells.Besides, miR-876-5p was selected out as a downstream molecule of SNHG17 in astrocytoma.ERLIN2 was determined to be targeted by miR-876-5p.ERLIN2 mRNA and protein levels were lessened by miR-876-5p overexpression and SNHG17 beer button down shirts for men silence.Additionally, miR-876-5p overexpression decelerated the biological processes of astrocytoma cells, so did ERLIN2 knockdown.

More importantly, the impacts of SNHG17 down-regulation on the malignant behaviors of astrocytoma cells were counteracted by overexpressed ERLIN2 or inhibited miR-876-5p.Conclusions SNHG17 could induce the progression of astrocytoma by sponging miR-876-5p to elevate the expression of ERLIN2.This study indicated that SNHG17 has a high potential to be a therapeutic target for astrocytoma.